The History of Cocaine
Long before cocaine was extracted from the coca plant, the leaves were chewed by the Indians of Peru and other South American
countries. This practice began before recorded history, so our knowledge is derived totally from archaeological sources. Line
drawings on pottery found in northwestern South America show evidence that coca chewing was part of the culture before the rise
of the Incan Empire, perhaps as early as 3,000 B.C., and that its effects on mood and behavior were very profound and much
appreciated by the Indians.
The coca plant was considered to be a gift of the gods and was used during religious rituals, burials and for other special
purposes. By the time the Spaniards arrived in the 16th century, the Incan Empire was in decline. By this time, coca was no
longer used only by the ruling class or only in association with ritual. The Spaniards, at first, tried to prevent the Indians from
using coca, because they believed it was a barrier to conversion to Christianity. Later, it became a practice to pay the Indians in
coca leaves for their work. The Spaniards could thereby force enormous amounts of work from them in the gold and silver mines
despite difficult conditions in the high altitudes.
Coca leaves, along with coffee, tea, and tobacco, were brought to Europe from South America by the explorers in the 16th
century, but unlike the others, coca leaves were unpopular until the 19th century. This may have been due to deterioration of the
leaves during the journey, causing a great loss of potency. In 1862, Albert Niemann finally extracted a purified cocaine from a
crystalline substance derived from coca leaves.
Cocaine was highly regarded in the 1880's and 1890's, and many prominent figures advocated the therapeutic use of cocaine:
Pope Leo XII, Sigmund Freud, Jules Verne, and Thomas Edison all endorsed its use and in 1888, Coca-cola, which originally
contained cocaine, advertised itself as "the drink that relieves exhaustion." (Coca-cola has since removed cocaine from the
contents of their drink and replaced it with caffeine.)
The abuse of cocaine was largely non-existent in the United States until the 1960's, except among entertainers and jazz musicians.
The use of the drug has been prohibited, both in patent medicines and for recreational use, since 1914.
The natives of the Andes still chew the unprocessed leaves for their stimulating effect. They often mix these with ashes or lime
and, it is said, they can go for days without feeling hunger or fatigue. The habitual chewer, however, has an unsteady gait,
green-crusted teeth, incurable insomnia, and general apathy.
Cocaine Addiction
Cocaine can be introduced into the body by sniffing, swallowing, or injecting it to produce its characteristic effects. Only pure
cocaine or crack can be smoked however. Outside of South America, where cocaine is chewed and absorbed by the membranes of
the mouth, stomach and intestines, cocaine is most frequently used in the form of powder. Powder is readily absorbed from all
mucous membranes such as the lining of the mouth, nasal passages, and gastrointestinal tract.
Powder is the preferred form, because it is easier to smuggle across the national borders than coca leaves. To increase profits,
cocaine hydrochloride is diluted with sugar and other drugs, thus exposing the user to other unknown and potentially dangerous
substances.
"Snorting" is the most popular way to take cocaine today. Within seconds, there is a numbing sensation in the nose which lasts
about five minutes. Then there is a gradual sense of exhilaration, euphoria and increased energy, and then a "high" that peaks in
ten to twenty minutes and then subsides. In an attempt to maintain their highs, users will continue to snort every thirty minutes or
so until their supply is gone.
Many frequent and more experienced cocaine users administer the drug through the veins. An intense "rush" is experienced within
just a minute or two. The rush wears off within thirty minutes, and as with snorting, the users will repeat the injections as long as
the drug is available. Smoking of coca paste is widespread in Peru, Ecuador, Columbia, and Bolivia, where this form is in easy
access. The effects derived from smoking are short-lived and users sometimes continue to smoke the paste for several hours. In
1985, coca paste was not being imported to the United States on a large scale basis, but since the crude processing of paste is
cheaper to produce than cocaine hydrochloride, this situation may change.
Users of cocaine have said that the using the drug was more important than food, sex, friends, family, or jobs. Their main
concern was how to ease the undesirable physical effects of being without the drug, and that, in itself, tells us why we shouldn't
use it.
Effects of Cocaine on the Body
Cocaine produces anesthetic effects by interfering with the transmission of information from one nerve cell to another. Although
used as a local anesthetic in eye surgery, it was soon found to damage the cornea and had other unwanted side effects.
Cocaine is a potent vasoconstrictor, which narrows (or constricts) the blood vessels. It increases the respiration rate and body
temperature, and also induces vomiting. At high dosages, tremors and convulsions may result. These stimulating effects can
rapidly lead to a collapse of the central nervous system, which may then lead to respiratory failure and/or cardiac arrest and finally
to death.
After repeated exposure to cocaine, certain areas in the limbic system (a group of structures of the brain that are concerned with
emotion and motivation) are more susceptible to a type of seizure that resembles an epileptic fit.
Cocaine causes profound loss of appetite, leading to severe weight loss and nutritional imbalance. It also causes sleep loss. The
symptoms of cocaine psychosis usually include paranoia; delusions of persecution; visual, auditory, and tactile (touch)
hallucinations; an increase in irrationality; restlessness; suspiciousness; depression; and a lack of motivation.
Because of increased demands on the heart during cocaine use, people with heart problems, such as hypertension or
cardiovascular disease, are more prone to fatal reactions. There are rare cases of cerebral hemorrhages (bleeding from the brain)
occurring from acute increases in the blood pressure.
If cocaine is taken through the veins, unsterile syringes can cause infections and disease. These infections can include Hepatitis B,
blood poisoning, inflammation of the lining and valves of the heart and, of course, AIDS.
Smoking cocaine paste produces severe complications: bronchitis, persistent coughing, blurred vision, and pulmonary
dysfunction of circulation. Chronic and compulsive cocaine use leads to depression, anxiety, irritability, and other psychological
complaints along with those previously mentioned. Despite the fact that continued use may not reduce the undesirable effects of
withdrawal, as long as the drug is available, users find it very difficult to do without cocaine.
Information on Cocaine thanks to http://www.angelfire.com
Chemical Make-up of Cocaine
| NAME: | Cocaine |
| CHEMICAL NAME: | [1R-(exo,exo)]-3-(Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester |
| ALTERNATE CHEMICAL NAMES: | 3beta-hydroxy-1alphaH, 5alphaH-tropane-2beta-carboxylic acid methyl ester benzoate |
| ALTERNATE CHEMICAL NAMES: | 2beta-carbomethyoxy-3beta-benzoxytropane, ecgonine methyl ester benzoate |
| ALTERNATE CHEMICAL NAMES: | l-cocaine, beta-cocaine, benzoylmethyl-ecgonine |
| CHEMICAL FORMULA | C17H21NO4 |
| MOLECULAR WEIGHT | 303.36 |
| MELTING POINT | 98° (monoclinic tablets) |
| MELTING POINT | 195° (Hydrochloride) |
| MELTING POINT | 58-63° (Nitrate dihydrate) |
How to make Cocaine